Blood levels of insulin-like growth factors I and II in neonates of non-insulin-dependent diabetic rats
| Autor: | J. Levy, J. R. Gavin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism medicine.medical_treatment Pregnancy in Diabetics Radioimmunoassay Diabetes Mellitus Experimental Rats Sprague-Dawley Insulin-like growth factor Endocrinology Insulin-Like Growth Factor II Pregnancy Reference Values Diabetes mellitus Internal medicine Blood plasma Internal Medicine medicine Glucose homeostasis Animals Insulin-Like Growth Factor I Analysis of Variance biology business.industry Insulin General Medicine medicine.disease Streptozotocin Rats Animals Newborn Diabetes Mellitus Type 2 Insulin-like growth factor 2 biology.protein Gestation Female business medicine.drug |
| Zdroj: | Acta diabetologica. 31(3) |
| ISSN: | 0940-5429 |
| Popis: | Circulating levels of insulin like growth factor I (IGF-I) and insulin like growth factor II (IGF-II) were evaluated in plasma samples during the first 72 h of life in neonates of diabetic and control mother rats. Diabetes had been induced in the diabetic dams by streptozotocin at 2 days of age. The rats developed non-insulin dependent diabetes (at 6 weeks of age) and became pregnant at 11 weeks of age. Maternal blood glucose levels were higher in the diabetic mothers (P0.05) during the last two-thirds of gestation. Complications occurred at the end of 7.1% of the diabetic pregnancies but none of the controls. Analysis of neonates plasma glucose, IGF-I, and IGF-II concentrations in the first 12, 24, 48, and 72 h after birth revealed higher glucose levels in neonates of diabetic mothers at 72 h compared with controls (118 +/- 7 vs 85 +/- 5 mg/dl, P0.05) but there was no difference in IGF-I or IGF-II levels between the groups at any time point. Thus, acquired impaired glucose homeostasis may be seen in neonates of mildly diabetic mothers at early stages of their life but their circulating insulin-like growth factors levels are normal. These data do not support the proposition that fetal IGF-I and -II affect the outcome of pregnancies complicated by mild diabetes in the rodent. |
| Databáze: | OpenAIRE |
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