Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Autor:	Carol A. Gilchrist, Biplob Hossain, Poonum S. Korpe, A. S. G. Faruque, Mamun Kabir, Tahmeed Ahmed, Heather Cook, Rashidul Haque, Jeffrey W. Priest, William A. Petri, Kevin L Steiner, Jennie Z. Ma
Rok vydání:	2019
Předmět:	Microbiology (medical) Immunoglobulin A mucosal 030231 tropical medicine Antibodies Protozoan Cryptosporidium Immunoglobulin G 03 medical and health sciences 0302 clinical medicine Antigen Immunity medicine Animals Humans Prospective Studies 030212 general & internal medicine Child Prospective cohort study Feces Bangladesh biology cryptosporidiosis business.industry Cp23 Mucous membrane biology.organism_classification Infectious Diseases medicine.anatomical_structure Sporozoites Immunology biology.protein Brief Reports fecal business IgA
Zdroj:	Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
ISSN:	1537-6591 1058-4838
Popis:	In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450c99e9fb19442d64d3eb93aaccdb7 https://doi.org/10.1093/cid/ciz430 Zobrazit plný text záznamu