Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN-Brazil initiative
Autor: | Poliana X. C. Andrade, Carolina Céspedes-Garro, Adrián LLerena, Eduardo Tarazona-Santos, Alexandre C. Pereira, Bernardo L. Horta, Camila Zolini, Fernanda Rodrigues-Soares, Fernanda S G Kehdy, Marla M. Aquino, Julia Sampaio-Coelho, Maria Fernanda Lima-Costa, Mauricio Lima Barreto |
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Rok vydání: | 2017 |
Předmět: |
Heredity
Pharmacogenomic Variants Population CYP2C19 Biology 030226 pharmacology & pharmacy Polymorphism Single Nucleotide 03 medical and health sciences Race (biology) 0302 clinical medicine Gene Frequency Databases Genetic Genetics Humans Healthcare Disparities education CYP3A5 Allele frequency Pharmacology education.field_of_study Racial Groups Health Status Disparities Pedigree Phenotype Haplotypes Genetic marker Pharmacogenetics 030220 oncology & carcinogenesis Genetic structure Molecular Medicine Brazil Demography |
Zdroj: | The pharmacogenomics journal. 18(6) |
ISSN: | 1473-1150 |
Popis: | We present allele frequencies involving 39 pharmacogenetic biomarkers studied in Brazil, and their distribution on self-reported race/color categories that: (1) involve a mix of perceptions about ancestry, morphological traits, and cultural/identity issues, being social constructs pervasively used in Brazilian society and medical studies; (2) are associated with disparities in access to health services, as well as in their representation in genetic studies, and (3), as we report here, explain a larger portion of the variance of pharmaco-allele frequencies than geography. We integrated a systematic review of studies on healthy volunteers (years 1968–2017) and the analysis of allele frequencies on three population-based cohorts from northeast, southeast, and south, the most populated regions of Brazil. Cross-validation of results from these both approaches suggest that, despite methodological heterogeneity of the 120 studies conducted on 51,747 healthy volunteers, allele frequencies estimates from systematic review are reliable. We report differences in allele frequencies between color categories that persist despite the homogenizing effect of >500 years of admixture. Among clinically relevant variants: CYP2C9*2 (null), CYP3A5*3 (defective), SLCO1B1-rs4149056(C), and VKORC1-rs9923231(A) are more frequent in Whites than in Blacks. Brazilian Native Americans show lower frequencies of CYP2C9*2, CYP2C19*17 (increased activity), and higher of SLCO1B1-rs4149056(C) than other Brazilian populations. We present the most current and informative database of pharmaco-allele frequencies in Brazilian healthy volunteers. |
Databáze: | OpenAIRE |
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