Monocyte-derived inhibitor of interleukin 1 induced by human cytomegalovirus
| Autor: | B C Rodgers, D M Scott, J Mundin, J G Sissons |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Interleukin 2
Human cytomegalovirus Time Factors viruses Immunology Congenital cytomegalovirus infection Cytomegalovirus Biology Virus Replication Microbiology Virus Monocytes Cell Line Species Specificity Virology medicine Humans Immunosuppression Therapy Interleukin medicine.disease Molecular Weight Viral replication Cell culture Insect Science Interleukin 19 Interleukin-2 medicine.drug Interleukin-1 Research Article |
| Zdroj: | Journal of virology. 55(3) |
| ISSN: | 0022-538X |
| Popis: | It has previously been shown that human cytomegalovirus (HCMV) can exert immunosuppressive effects, and it has been suggested that these may be mediated by monocytes, although the mechanism is unclear. We showed that infection of human monocytes with the AD169 strain of HCMV abrogates their production of interleukin 1 (IL-1) activity. This was associated with the release from infected monocytes of an inhibitor of IL-1 activity which was also released after HCMV infection of the U937 macrophage-like cell line. The inhibitor of IL-1 activity is a protein with an apparent molecular weight of ca. 95,000. This action of HCMV strain AD169 was virus specific and required infectious virus but occurred without virus replication or detectable expression of viral proteins. This effect may account, at least in part, for the previously observed immunosuppressive properties of HCMV. |
| Databáze: | OpenAIRE |
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