Multiple plastic stents versus covered metal stent for treatment of anastomotic biliary strictures after liver transplantation: a prospective, randomized, multicenter trial

Autor: Leena Kylänpää, I. Parzanese, Andrea Tal, Paolo Cantù, Fabian Finkelmeier, Mireen Friedrich-Rust, Joerg G. Albert, V. Penndorf, Natalie Filmann, Alexander Dechêne, Stefan Zeuzem, Marianne Udd, Andreas A. Schnitzbauer
Přispěvatelé: Department of Surgery, II kirurgian klinikka, University of Helsinki, Clinicum, HUS Abdominal Center
Rok vydání: 2017
Předmět:
Male
medicine.medical_treatment
Medizin
Constriction
Pathologic
Liver transplantation
THERAPY
DISEASE
law.invention
0302 clinical medicine
Randomized controlled trial
Bile Ducts
Extrahepatic
law
Self-expandable metallic stent
Clinical endpoint
Prospective Studies
Prospective cohort study
Cholangiopancreatography
Endoscopic Retrograde
OUTCOMES
COMPLICATIONS
Cholestasis
Anastomosis
Surgical
Gastroenterology
Middle Aged
ENDOSCOPIC TREATMENT
Prosthesis Failure
3. Good health
Treatment Outcome
030220 oncology & carcinogenesis
Retreatment
Female
030211 gastroenterology & hepatology
Radiology
Plastics
Adult
medicine.medical_specialty
Self Expandable Metallic Stents
STENOSIS
03 medical and health sciences
Multicenter trial
MANAGEMENT
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
business.industry
Stent
3126 Surgery
anesthesiology
intensive care
radiology
Liver Transplantation
Surgery
Clinical trial
business
Zdroj: Gastrointestinal Endoscopy. 86:1038-1045
ISSN: 0016-5107
Popis: Background and Aims: Treatment of anastomotic biliary strictures (ABSs) after orthotopic liver transplantation by endoscopic insertion of multiple plastic stents (MPSs) is well established. The use of covered self-expandable metal stents (cSEMSs) for this indication is less investigated. Methods: In an open-label, multicenter, randomized trial, patients with confirmed ABSs were randomly assigned 1:1 to receive either an MPS or a cSEMS. The primary endpoint was the number of endoscopic interventions until ABS resolution. Secondary endpoints were frequency of adverse events, treatment success rates, and time to treatment success and recurrence of ABS during follow-up of at least 1 year. Results: Fifty-eight patients were included between 2012 and 2015, and 48 patients completed follow-up. Patients receiving MPS (n = 24) underwent a median of 4 (range, 3-12) endoscopic retrograde cholangiography examinations, whereas those in the cSEMS group (n = 24) underwent a median of 2 (range, 2-12) sessions until ABS resolution (P
Databáze: OpenAIRE
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