Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease
| Autor: | Qi Kong, Xin Ma, Yunqian Guan, Xiangying Du, Chen Wang, Jun-Xuan Lyu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Chemokine
medicine.medical_specialty Medicine (General) Neurology 030204 cardiovascular system & hematology Coronary artery Continuous variable Ischemic cerebrovascular disease 03 medical and health sciences 0302 clinical medicine R5-920 Plasma RANTES Internal medicine medicine In patient Computed tomography angiography Cervicocephalic artery biology medicine.diagnostic_test business.industry Cardiocerebral atherosclerosis burden medicine.disease Coronary arteries medicine.anatomical_structure Cerebral atherosclerosis 030220 oncology & carcinogenesis biology.protein Cardiology Original Article Cerebral vessel business |
| Zdroj: | Chronic Diseases and Translational Medicine Chronic Diseases and Translational Medicine, Vol 6, Iss 1, Pp 46-54 (2020) |
| ISSN: | 2589-0514 |
| Popis: | Background: Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD. Methods: Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by “cardio-cerebral AS burden (CCAB)” as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models. Results: A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD (r = 0.786, P |
| Databáze: | OpenAIRE |
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