Thyroid cancer and inflammation

Autor: Maria Domenica Castellone, Valentina Guarino, Elvira Avilla, Rosa Marina Melillo
Přispěvatelé: Guarino, Valentina, Castellone, MARIA DOMENICA, Avilla, Elvira, Melillo, ROSA MARINA
Rok vydání: 2009
Předmět:
Zdroj: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2010, 321 (1), pp.94. ⟨10.1016/j.mce.2009.10.003⟩
Molecular and cellular endocrinology
(2010).
info:cnr-pdr/source/autori:Guarino, V [ 1 ] ; Castellone, MD [ 1 ] ; Avilla, E [ 1 ] ; Melillo, RM [ 1,2 ]/titolo:Thyroid cancer and inflammation/doi:/rivista:Molecular and cellular endocrinology (Print)/anno:2010/pagina_da:/pagina_a:/intervallo_pagine:/volume
ISSN: 1872-8057
0303-7207
Popis: International audience; Some cancer types are strongly associated with chronic inflammatory or infectious diseases whereas others are not, but an inflammatory component is present in most human neoplastic lesions. This review focuses on various aspects of thyroid cancer and inflammation. The incidence of thyroid cancer, in particular of well-differentiated papillary thyroid carcinomas (PTCs), is increased in autoimmune thyroid diseases such as Hashimoto's thyroiditis. Thyroid cancer often has an inflammatory cell infiltrate, which includes lymphocytes, macrophages, dendritic cells and mast cells, whose role in thyroid cancer is still not completely understood. However, most experimental evidence suggests these cells exert a pro-tumorigenic function. Moreover, oncoproteins typically expressed in human PTCs, such as RET/PTC, RAS, and BRAF, trigger a pro-inflammatory programme in thyreocytes. These data suggest that inflammatory molecules are promising targets for thyroid cancer therapy.
Databáze: OpenAIRE
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