Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial.: Fat structuring modifies postprandial metabolism
| Autor: | Marie-Caroline Michalski, Hubert Vidal, Corinne Louche-Pelissier, Laure Gabert, Denis Lairon, Michel Desage, Gaëlle Pineau, Martine Laville, Catherine Defoort, Stéphanie Lambert-Porcheron, Jocelyne Drai, Cécile Vors, Sabine Danthine |
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| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RH), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Service de Biochimie Générale, Métabolique et Moléculaire, Hospices Civils de Lyon (HCL), Laboratoire de Biochimie, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gembloux Agro-Bio Tech [Gembloux], Université de Liège, This work was funded by the Centre National Interprofessionnel de l'Economie Laitière (CNIEL). CV received funding for PhD study by INRA and CNIEL. CV received a Research Prize from the Foundation Nestlé France. HV received financial support from Ezus-Lyon1. The funding agencies had no role in the data analysis., Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble, Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male MESH: Hyperlipidemias 030309 nutrition & dietetics Hunger Medicine (miscellaneous) Fatty Acids Nonesterified MESH: Carbon Dioxide Intestinal absorption Body Mass Index Feces 0302 clinical medicine MESH: Fatty Acids Omega-3 Hyperlipidemia Chylomicrons MESH: Obesity Insulin Meals MESH: Lipid Metabolism chemistry.chemical_classification emulsion 0303 health sciences MESH: Fatty Acids Nonesterified Nutrition and Dietetics Cross-Over Studies MESH: Kinetics Fatty Acids chylomicron MESH: Feces Postprandial Period MESH: Hunger 3. Good health MESH: Fatty Acids MESH: Chylomicrons Postprandial Breath Tests MESH: Postprandial Period MESH: Calorimetry Indirect MESH: Triglycerides Adult medicine.medical_specialty MESH: Intestinal Absorption stable isotopes 030209 endocrinology & metabolism Context (language use) Hyperlipidemias MESH: Insulin MESH: Cross-Over Studies MESH: Body Mass Index 03 medical and health sciences Lipid oxidation Internal medicine MESH: Meals Fatty Acids Omega-3 medicine Humans Obesity Triglycerides MESH: Breakfast Breakfast MESH: Humans Hypertriglyceridemia MESH: Apolipoprotein B-48 Fatty acid MESH: Adult Calorimetry Indirect Carbon Dioxide medicine.disease Lipid Metabolism MESH: Male MESH: Breath Tests Kinetics Endocrinology chemistry Intestinal Absorption MESH: Blood Glucose Apolipoprotein B-48 [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Chylomicron |
| Zdroj: | American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 2013, 97 (1), pp.23-36. ⟨10.3945/ajcn.112.043976⟩ The American Journal of Clinical Nutrition The American Journal of Clinical Nutrition, 2013, 97 (1), pp.23-36. ⟨10.3945/ajcn.112.043976⟩ |
| ISSN: | 1938-3207 0002-9165 |
| DOI: | 10.3945/ajcn.112.043976⟩ |
| Popis: | International audience; BACKGROUND: Prolonged postprandial hypertriglyceridemia is a potential risk factor for cardiovascular diseases. In the context of obesity, this is associated with a chronic imbalance of lipid partitioning oriented toward storage and not toward β-oxidation. OBJECTIVE: We tested the hypothesis that the physical structure of fat in a meal can modify the absorption, chylomicron transport, and further metabolic handling of dietary fatty acids. DESIGN: Nine normal-weight and 9 obese subjects were fed 40 g milk fat (+[(13)C]triacylglycerols), either emulsified or nonemulsified, in breakfasts of identical composition. We measured the postprandial triacylglycerol content and size of the chylomicron-rich fraction, plasma kinetics of [(13)C]fatty acids, exogenous lipid oxidation with breath-test/indirect calorimetry, and fecal excretion. RESULTS: The emulsified fat resulted in earlier (>1 h) and sharper chylomicron and [(13)C]fatty acid peaks in plasma than in spread fat in both groups (P < 0.0001). After 2 h, the emulsified fat resulted in greater apolipoprotein B-48 concentrations (9.7 ± 0.7 compared with 7.1 ± 0.9 mg/L; P < 0.05) in the normal-weight subjects than did the spread fat. In the obese subjects, emulsified fat resulted in a 3-fold greater chylomicron size (218 ± 24 nm) compared with the spread fat (P < 0.05). The emulsified fat induced higher dietary fatty acid spillover in plasma and a sharper (13)CO(2) appearance, which provoked increased exogenous lipid oxidation in each group: from 45% to 52% in normal-weight subjects (P < 0.05) and from 40% to 57% in obese subjects (P < 0.01). CONCLUSION: This study supports a new concept of "slow vs fast fat," whereby intestinal absorption can be modulated by structuring dietary fat to modulate postprandial lipemia and lipid β-oxidation in humans with different BMIs. This trial was registered at clinicaltrials.gov as NCT01249378. |
| Databáze: | OpenAIRE |
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