Studies of the etiology of obesity in Pima Indians
| Autor: | Stephen Lillioja, David M. Mott, Barbara V. Howard, Clifton Bogardus, Eric Ravussin, W. C. Knowler, James E. Foley, Peter H. Bennett |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Lipolysis medicine.medical_treatment Medicine (miscellaneous) Body Mass Index chemistry.chemical_compound Insulin resistance Internal medicine Prevalence medicine Humans Obesity Adenosine Triphosphatases Lipoprotein lipase Nutrition and Dietetics Fatty acid metabolism Gastric emptying business.industry Insulin Fatty Acids Arizona Glucose transporter Middle Aged medicine.disease Lipoprotein Lipase Glucose Endocrinology Adipose Tissue chemistry Body Composition Indians North American Female Insulin Resistance Energy Metabolism business |
| Zdroj: | The American Journal of Clinical Nutrition. 53:1577S-1585S |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/53.6.1577s |
| Popis: | Studies have been conducted on various metabolic characteristics of lean and obese Pima Indians, including studies of fat-cell morphology, glucose transport, and lipolysis; lipoprotein lipase activities; sodium-potassium ATPase in red cells, adipocytes, and fibroblasts; lipids and lipoprotein metabolism; fatty acid metabolism; and sterol balance. Insulin concentrations, insulin binding, insulin action on glucose disposal, fatty acid metabolism, and islet function were compared in lean and obese individuals, and the relationship between insulin resistance and muscle morphology was explored. To explore potential abnormalities in energy balance, calorie intake and gastric emptying were compared in lean and obese Pimas and measurements of energy expenditure were performed. The data suggest that there are multiple metabolic differences that accompany obesity in Native Americans. A lower metabolic rate was a determinant of future weight gain, and abnormalities in use of free fatty acids and cell insulin action were suggested, which emphasize the need for further studies in these areas. |
| Databáze: | OpenAIRE |
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