Dopaminergic Influence on the Cardiovascular and Hormonal Responses to Cold Stress in Hypertensive Patients
| Autor: | Pablo Forte, Ramón Arreaza, Augusta Luchsinger, Eduardo Romero, Juanita Gómez, Otto Hernández, Manuel Velasco |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
medicine.medical_specialty Mean arterial pressure Aldosterone business.industry Dopaminergic Cold pressor test General Medicine Plasma renin activity Bromocriptine Domperidone chemistry.chemical_compound Endocrinology chemistry Internal medicine Heart rate Medicine Pharmacology (medical) business medicine.drug |
| Zdroj: | American journal of therapeutics. 2(3) |
| ISSN: | 1536-3686 |
| Popis: | Immersion of one hand into ice water (cold pressor test) in eight hypertensive subjects induces elevation of mean arterial pressure, increase in heart rate, and no significant changes of plasma renin activity and plasma aldosterone concentrations. Domperidone, a DA2 dopaminergic antagonist, attenuates heart rate increase induced by the cold pressor test, and the combination of bromocriptine, a known DA2 dopaminergic agonist, with domperidone again provoked a heart rate increase during the cold pressor test. Domperidone caused an increase of both plasma renin activity and plasma aldosterone concentrations, which were reversed by bromocriptine. These results suggest that a dopamine-receptor stimulation is taking place during the cold pressor test. |
| Databáze: | OpenAIRE |
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