The thrombin peptide, TP508, enhances cytokine release and activates signaling events

Autor: Antonella Naldini, Fabio Carraro, C. Bernini, Cosima T. Baldari, Silvia Rossi Paccani, Darrell H. Carney, Michael J. Keherly
Rok vydání: 2004
Předmět:
Lipopolysaccharides
thrombin
thrombin peptide
TP508
interleukin-1
interleukin-2
Erk
p38
mononuclear leucocytes
Jurkat
U937
Physiology
medicine.medical_treatment
p38 Mitogen-Activated Protein Kinases
Biochemistry
Jurkat cells
Jurkat Cells
Endocrinology
SOCS3
Phosphorylation
Cells
Cultured
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
U937 cell
U937 Cells
Cell biology
Cytokine
Cytokines
Signal transduction
Signal Transduction
medicine.drug
Interleukin 2
Cell Survival
Immunoblotting
Enzyme-Linked Immunosorbent Assay
Biology
Cellular and Molecular Neuroscience
Thrombin
medicine
Humans
Phytohemagglutinins
Dose-Response Relationship
Drug
Suppressor of cytokine signaling 1
Oligonucleotides
Antisense
Molecular biology
Enzyme Activation
Kinetics
Leukocytes
Mononuclear
Peptides
Zdroj: Peptides. 25:1917-1926
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2004.05.017
Popis: The thrombin peptide, TP508, accelerates tissue repair and initiates a cascade of cellular events. We have previously shown that α-thrombin induces cytokine expression in human mononuclear cells. We, therefore, investigated the possibility that TP508 might activate cytokine production and intracellular signaling pathways associated with cytokine activation. Our results show that TP508 induces cytokine expression in human mononuclear cells. TP508 treatment enhances extracellular signal-regulated kinase (Erk1/2) activities in U937 cells, as well as Erk1/2 and p38 activation in Jurkat T cells. These data support the hypothesis that TP508 may accelerate tissue repair through the activation of the inflammatory response.
Databáze: OpenAIRE
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