Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia
| Autor: | Faraneh Vargha-Khadem, B. G. R. Neville, A D Leiper, J M Chessells, Deborah Christie, Margaret P. Battin |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Childhood leukemia Developmental Disabilities Intelligence Neurological disorder Education Leukemic Infiltration Recurrence Acute lymphocytic leukemia medicine Humans Child Radiation Injuries Somnolence Syndrome Growth Disorders Radiotherapy business.industry Cognitive disorder Age Factors Neuropsychology Brain Infant Sequela Total body irradiation medicine.disease Leukemia Lymphoid Surgery Methotrexate Child Preschool Pediatrics Perinatology and Child Health Female Cranial Irradiation Nervous System Diseases Cognition Disorders business Whole-Body Irradiation Research Article |
| Zdroj: | Archives of Disease in Childhood. 70:275-280 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.70.4.275 |
| Popis: | Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The postirradiation somnolence syndrome was common after cranial radiotherapy. All children had mild/soft neurological signs, mostly of coordination. None had a major motor disability. All but the youngest child had cataracts; two children required an operation for these. All children were growth hormone deficient. Verbal IQ, attention, and concentration were selectively reduced (with respect to normative levels). The time between the two treatments, age at relapse, and higher doses of radiotherapy all correlated with cognitive outcome, with girls showing greater impairments than boys. Only two children were performing at age appropriate levels on measures of academic achievement. It is concluded that neurological and neuropsychological morbidity is significantly increased by the current treatments prescribed after the relapse of leukaemia. |
| Databáze: | OpenAIRE |
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