pH Response Pathways in Fungi: Adapting to Host-derived and Environmental Signals
| Autor: | Kyla Selvig, J. Andrew Alspaugh |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Saccharomyces cerevisiae
Review Article Signal transduction Bioinformatics Microbiology Aspergillus nidulans 03 medical and health sciences Candida albicans Transcription factor 030304 developmental biology 0303 health sciences biology 030306 microbiology Host (biology) biology.organism_classification PacC Yeast Cell biology Infectious Diseases Cryptococcus neoformans Rim101 Adaptation |
| Zdroj: | Mycobiology |
| ISSN: | 2092-9323 1229-8093 |
| Popis: | Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators have studied various fungal species to define conserved pH-responsive signaling pathways. One of these pathways, known as the Pal/Rim pathway, is activated in response to alkaline pH signals, ultimately targeting the PacC/Rim101 transcription factor. Although the central signaling components are conserved among divergent filamentous and yeast-like fungi, there is some degree of signaling specificity between fungal species. This specificity exists primarily in the downstream transcriptional targets of this pathway, likely allowing differential adaptation to species-specific environmental niches. In this review, the role of the Pal/Rim pathway in fungal pH response is discussed. Also highlighted are functional differences present in this pathway among human fungal pathogens, differences that allow these specialized microorganisms to survive in the various micro-environments of the infected human host. |
| Databáze: | OpenAIRE |
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