Effect of lithium chloride on the neurosecretory system of the rat hypothalamus
| Autor: | N. N. Samoilov, A. V. Rychko, A. N. Yavorskii |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System medicine.medical_specialty Time Factors Lithium (medication) Cell Count Lithium General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Recovery period Chlorides Internal medicine Hormone formation medicine Animals Neurons Neurosecretion General Neuroscience Median Eminence General Medicine Rats Endocrinology chemistry Hypothalamus RNA Lithium chloride Liberation Supraoptic Nucleus Paraventricular Hypothalamic Nucleus medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 83:36-38 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00802800 |
| Popis: | The response of the hypothalamic-pituitary neurosecretory system (HPNS) of rats to a single and repeated injection (200 mg/kg each time) of lithium chloride was studied by quantitative cytochemical analysis. The response of the HPNS was found to depend directly on the dose of lithium given and to consist of activation of synthesis and liberation of neurosecretion after a single dose of LiCl or inhibition of hormone formation in the hypothalamus and exhaustion of the reserves of neurosecretion in the neurohypophysis after a course of injections. In the recovery period (7--30 days after stopping the course of injections of LiCl) the previous state of the HPNS was gradually restored. |
| Databáze: | OpenAIRE |
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