Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study
| Autor: | Baré, Marisa, Lleal, Marina, Sevilla-Sánchez, Daniel, Ortonobes, Sara, Herranz, Susana, Ferrandez, Olivia, Corral-Vázquez, Celia, Molist, Núria, Nazco, Gloria Julia, Martín-González, Candelaria, Márquez, Miguel Ángel, Group, on behalf of the MoPIM Study Group on behalf of the MoPIM Study |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Sex perspective
multimorbidity Health Toxicology and Mutagenesis adverse drug reaction Adverse drug reaction Outcomes of care Public Health Environmental and Occupational Health Multimorbidity In-hospital mortality potentially inappropriate medication Network analysis Potentially inappropriate medication outcomes of care network analysis sex perspective in-hospital mortality |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 20 Issue 4 Pages: 3639 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph20043639 |
| Popis: | There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (≥65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% ≥85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode. |
| Databáze: | OpenAIRE |
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