Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test
| Autor: | Caroline Montelius, Jens F. Rehfeld, Charlotte Erlanson-Albertsson, Katarzyna Szwiec, Marek Kardas, Liudmyla Lozinska, Björn Weström, Stefan Pierzynowski |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Swine media_common.quotation_subject Appetite Biology Carbohydrate metabolism Critical Care and Intensive Care Medicine Thylakoids Internal medicine OGTT medicine Animals media_common Cholecystokinin Meal Nutrition and Dietetics Body Weight digestive oral and skin physiology Area under the curve food and beverages Glucose Tolerance Test Ghrelin High-fat diet Glucose Endocrinology Intestinal Absorption Glycemic Index Thylakoid Hormone |
| Zdroj: | Clinical Nutrition. 33:1122-1126 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2013.12.009 |
| Popis: | SummaryBackground & aimsDietary chloroplast thylakoids have previously been found to reduce food intake and body weight in animal models, and to change metabolic profiles in humans in mixed-food meal studies. The aim of this study was to investigate the modulatory effects of thylakoids on glucose metabolism and appetite-regulating hormones during an oral glucose tolerance test in pigs fed a high fat diet.MethodsSix pigs were fed a high fat diet (36 energy% fat) for one month before oral glucose tolerance test (1 g/kg d-glucose) was performed. The experiment was designed as a cross-over study, either with or without addition of 0.5 g/kg body weight of thylakoid powder.ResultsThe supplementation of thylakoids to the oral glucose tolerance test resulted in decreased blood glucose concentrations during the first hour, increased plasma cholecystokinin concentrations during the first two hours, and decreased late postprandial secretion of ghrelin.ConclusionDietary thylakoids may be a novel agent in reducing the glycaemic responses to high carbohydrate and high glycaemic index foods. Thylakoids may in the future be promising for treatment and prevention of diabetes, overweight and obesity. |
| Databáze: | OpenAIRE |
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