Antiviral flavonoids from the root bark of Morus alba L
| Autor: | Hong-Xi Xu, Wen-Cai Ye, Jiang Du, Ren-Wang Jiang, Paul Pui-Hay But, Zhen-Dan He |
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| Rok vydání: | 2003 |
| Předmět: |
Herpes simplex type 1 virus
Flavonoid Acyclovir Herpesvirus 1 Human Microbial Sensitivity Tests Plant Science Horticulture Pharmacognosy Antiviral Agents Plant Roots Biochemistry Inhibitory Concentration 50 Chlorocebus aethiops Botany Animals Bioassay Vero Cells Molecular Biology Flavonoids chemistry.chemical_classification Plants Medicinal Traditional medicine biology Biological activity General Medicine Moraceae biology.organism_classification chemistry visual_art Plant Bark visual_art.visual_art_medium Bark Morus Leachianone G |
| Zdroj: | Phytochemistry. 62:1235-1238 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/s0031-9422(02)00753-7 |
| Popis: | A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods. |
| Databáze: | OpenAIRE |
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