The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment: An analysis of the Dutch CAIRO5 trial
| Autor: | Karen Bolhuis, Marinde J.G. Bond, Martin J. Van Amerongen, Aysun Komurcu, Thiery Chapelle, Cornelis H.C. Dejong, Marc R.W. Engelbrecht, Michael F. Gerhards, Dirk J. Grünhagen, Thomas M. van Gulik, John J. Hermans, Koert P. De Jong, Geert Kazemier, Joost M. Klaase, Niels F.M. Kok, Wouter K.G. Leclercq, Mike S.L. Liem, Krijn P. van Lienden, I. Quintus Molenaar, Ulf P. Neumann, Gijs A. Patijn, Arjen M. Rijken, Theo M. Ruers, Cornelis Verhoef, Johannes H.W. de Wilt, Anne M. May, Cornelis J.A. Punt, Rutger-Jan Swijnenburg |
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| Přispěvatelé: | CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Surgery, CCA - Cancer biology and immunology, Oncology, CCA - Imaging and biomarkers, AII - Cancer immunology, CCA - Cancer Treatment and quality of life, Dutch Colorectal Cancer Group Liver Expert Panel, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Value, Affordability and Sustainability (VALUE) |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Cancer Research
EARLY RECURRENCE HEPATECTOMY BEVACIZUMAB Local treatment HEPATIC RESECTION CHEMOTHERAPY Colorectal cancer Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] Liver metastases All institutes and research themes of the Radboud University Medical Center Oncology SDG 3 - Good Health and Well-being Recurrence RISK-FACTORS SURVIVAL Resectability Human medicine CANCER PATIENTS Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] Outcome |
| Zdroj: | European Journal of Cancer, 183, 49-59. Elsevier Limited European Journal of Cancer, 183, 49-59. Pergamon Dutch Colorectal Cancer Group Liver Expert Panel 2023, ' The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment : An analysis of the Dutch CAIRO5 trial ', European Journal of Cancer, vol. 183, pp. 49-59 . https://doi.org/10.1016/j.ejca.2023.01.013 European journal of cancer European Journal of Cancer, 183, pp. 49-59 European Journal of Cancer, 183, 49-59 European Journal of Cancer, 183, 49-59. ELSEVIER SCI LTD European Journal of Cancer, 183, 49-59. Elsevier Ltd. |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2023.01.013 |
| Popis: | Contains fulltext : 291422.pdf (Publisher’s version ) (Open Access) BACKGROUND: Large inter-surgeon variability exists in technical anatomical resectability assessment of colorectal cancer liver-only metastases (CRLM) following induction systemic therapy. We evaluated the role of tumour biological factors in predicting resectability and (early) recurrence after surgery for initially unresectable CRLM. METHODS: 482 patients with initially unresectable CRLM from the phase 3 CAIRO5 trial were selected, with two-monthly resectability assessments by a liver expert panel. If no consensus existed among panel surgeons (i.e. same vote for (un)resectability of CRLM), conclusion was based on majority. The association of tumour biological (sidedness, synchronous CRLM, carcinoembryonic antigen and RAS/BRAF(V600E) mutation status) and technical anatomical factors with consensus among panel surgeons, secondary resectability and early recurrence ( |
| Databáze: | OpenAIRE |
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