Metabolic monitoring of transcorneal electrical stimulation in retinitis pigmentosa
| Autor: | Hanna Camenzind Zuche, Annekatrin Rickmann, Ursula Müller, Hendrik P. N. Scholl, Margarita G. Todorova, Maria Della Volpe-Waizel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty chemistry.chemical_element Stimulation Oxygen Retina Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Oxygen Consumption 0302 clinical medicine Ophthalmology Retinitis pigmentosa Electroretinography Humans Medicine Oximetry Prospective Studies Aged Monitoring Physiologic Oxygen saturation (medicine) Aged 80 and over business.industry Retinal Vessels Retinal Middle Aged medicine.disease Electric Stimulation Sensory Systems Phosphene medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Female business Retinitis Pigmentosa 030217 neurology & neurosurgery Follow-Up Studies Optic disc |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 258:79-87 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-019-04522-9 |
| Popis: | Transcorneal electrical stimulation (TES) is a novel treatment approach for patients with retinitis pigmentosa (RP). With progression of RP, loss of photoreceptors leads to less oxygen consumption and lower demand in the retina. Retinal oximetry (RO), as a non-invasive method to analyse oxygen saturation in retinal vessels, promises to be a useful therapy monitoring tool. The aim of our study was to observe changes in RO that would be attributed to therapeutic intervention. A total of 43 eyes of 22 subjects (11♀ 11♂) suffering from RP were examined at baseline, after the first stimulation, 1 week and 6 months after TES (OkuStim®). Stimulation was performed for 30 min weekly at 200% of the individual phosphene threshold, simultaneously on both eyes. The oxygen saturation was examined at baseline and following TES stimulation with the oxygen saturation tool of the Retinal Vessel Analyser (RVA; IMEDOS Systems UG, Jena, Germany). The global oxygen saturation parameters (in %), within 1.0–1.5 optic disc diameters from the disc margin, in retinal arterioles (A-SO2) and venules (V-SO2) were estimated and their difference (A-V SO2) was calculated. In addition, we evaluated the diameters (in μm) in the corresponding arterioles (D-A) and venules (D-V). ANOVA-based linear mixed-effects models were calculated with SPSS®. Six months after TES treatment, the mean A-SO2 increased (from 96.48 ± 12.27 to 100.15 ± 5.56%, p = 0.09), while the V-SO2 decreased (from 61.61 ± 12.78 to 59.79 ± 11.15%, p = 0.48). The A-V SO2, which represents the oxygen consumption of the retina, showed a statistically significant increase from 34.87 ± 9.38% at baseline to 41.36 ± 9.18% after 6 months (p = 0.02). TES had no influence on the D-A and D-V (p > 0.6). These data indicate that TES therapy in RP leads to an increased oxygen consumption of the retina. RO may thus serve as a sensitive monitoring method for TES therapy in RP. |
| Databáze: | OpenAIRE |
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