Role of hypotension induced by PGI2 on the control of depth and frequency of breathing
| Autor: | M.G. Clement, Triulzi Mo, G.C. Maggi, G. Aguggini |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Expiratory Time Baroreceptor business.industry Swine Respiration Prostacyclin General Medicine Vagotomy Epoprostenol Rhythm Pulmonary stretch receptors Anesthesia cardiovascular system Breathing Prostaglandins Medicine Animals Lung volumes Female Respiratory system Hypotension Sympathectomy business medicine.drug |
| Zdroj: | Prostaglandins and medicine. 5(6) |
| ISSN: | 0161-4630 |
| Popis: | We studied the respiratory response to infusion of prostacyclin (PGI2) in 7 anaesthetized pigs in an attempt to understand whether the changes in pattern of breathing were due to a direct action of the substance or to the concomitant hypotensive effect. The depth and frequency of breathing were analyzed in terms of the threshold-inhibition curve for termination of inspiration (VT/TI relationship) and of bulbo-pontine rhythm, estimated from inspiratory and expiratory time during occlusion of the airways at the end expiratory level (TE/TI relationship). This provide the central respiratory rhythm when the phasic lung volume receives no input from pulmonary stretch receptors. The hypotension induced by PGI2 increased pulmonary ventilation mainly through a change in VT and caused a slight rightward displacement of VT/TI relationship without modifying the slope of the curve. This effect seems to be vagally mediated. PGI2 also changed the bulbo-pontine rhythm. Our results show that PGI2 modifies the vagal discharge and bulbo-pontine rhythm by two opposite mechanisms: hypotension and an apparent direct action on carotid and aortic baroreceptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|