Leptin, Insulin, and Glucose Serum Levels in Large-for-Gestational-Age Infants of Diabetic and Non-Diabetic Mothers
| Autor: | Juan Manuel Guízar-Mendoza, Edgar Ulises San Vicente-Santoscoy, Norma Amador-Licona, M Martha Vela-Huerta, Carlos Aldana-Valenzuela, Javier Hernnández |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Leptin Male medicine.medical_specialty Cross-sectional study Endocrinology Diabetes and Metabolism medicine.medical_treatment Pregnancy in Diabetics Gestational Age Infant Newborn Diseases Fetal Macrosomia Endocrinology Insulin resistance Pregnancy Hyperinsulinism Internal medicine Diabetes Mellitus medicine Hyperinsulinemia Birth Weight Humans Insulin Obesity business.industry digestive oral and skin physiology Infant Newborn Gestational age medicine.disease Cross-Sectional Studies Pediatrics Perinatology and Child Health Female Insulin Resistance business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 21 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Background It has been suggested that hyperleptinemia could be caused by hyperinsulinemia in infants of diabetic mothers (IDMs). Aim To compare leptin, insulin, and glucose levels in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) infants. Methods A cross-sectional study was conducted in IDMs, infants of non-diabetic mothers (INDM) and AGA infants. Results Seventy-seven newborns were studied (11 IDM, 16 INDM, and 50 AGA infants). Leptin levels were significantly higher in LGA infants than in the AGA group and a trend for higher levels in IDM than NIDM was observed. Insulin levels and insulin resistance were significantly higher in IDMs. Glucose levels were lower in both groups of LGA infants. Conclusions We found insulin resistance, hyperinsulinism and hyperleptinemia in IDMs, and the trend of higher leptin levels in IDMs than INDMs shows that leptin could be related to insulin resistance in these infants. |
| Databáze: | OpenAIRE |
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