Correlation between clinicopathological characteristics of lung adenocarcinoma and the risk of venous thromboembolism
| Autor: | Wei Feng, Shu Zhang, Jin Zhao, Yuhui Zhang, Zhongyue Shi, Jiawen Yi, Yuan Zhang, Min Zhu, Bin Hu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms venous thromboembolism Adenocarcinoma of Lung Gastroenterology Correlation Postoperative Complications Risk Factors Internal medicine medicine Humans micropapillary subtype cardiovascular diseases Lung cancer RC254-282 Aged Neoplasm Staging Retrospective Studies histological classification Univariate analysis adenocarcinoma Lung business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Original Articles General Medicine Perioperative Middle Aged equipment and supplies medicine.disease lung cancer medicine.anatomical_structure Oncology Adenocarcinoma Original Article Female business Complication Venous thromboembolism |
| Zdroj: | Thoracic Cancer, Vol 13, Iss 2, Pp 247-256 (2022) Thoracic Cancer |
| ISSN: | 1759-7714 1759-7706 |
| DOI: | 10.1111/1759-7714.14260 |
| Popis: | Background Patients with primary lung adenocarcinoma are at increased risk of venous thromboembolism (VTE). However, lung adenocarcinoma characteristics differ across histological subtypes. Therefore, we performed comprehensive analyses on the clinicopathological characteristics of lung adenocarcinoma and risk of VTE. Methods A total of 952 surgically resected lung adenocarcinoma cases were reviewed and classified according to criteria of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS) /European Respiratory Society (ERS). The correlation between this classification and VTE risk was retrospectively analyzed. The risks of other clinicopathological features including pleural invasion, vascular invasion and associated surgical intervention risks were also assessed. Results Of the 952 patients, 100 (10.4%) cases experienced VTE events during the follow‐up period. Among those with VTE, 28 (28%) were found before surgery, 47 (47%) were found within 1 month after surgery, and 91 (91%) were found in hospital. Univariate analysis revealed that ages, extent of resection and presence of micropapillary features were predictive of VTE risk. Furthermore, multivariable analysis demonstrated that the presence of micropapillary features (subdistribution hazard ratio [SHR] 1.560, 95% CI: 1.043–2.330) and age >60 (SHR: 2.270, 95% CI:1.491–3.470) were associated with increased risk of VTE. After one year, the probability of developing VTE was 13.1% and 8.3% in patients with micropapillary features and those without, respectively. Conclusions VTE is a common complication for lung adenocarcinoma patients who undergo surgery, especially during the perioperative process and hospitalization. Presence of micropapillary subtype and age are positively associated with VTE risk. VTE is a common complication in lung adenocarcinoma patients who undergo surgery, especially during the perioperative process and hospitalization. Presence of micropapillary subtype and age are positively associated with VTE risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text