The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis
| Autor: | Solveig Petersen, Susanne Syberg, Niklas Rye Jørgensen, Ming Ding, T. M. Kvist, Peter Schwarz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Endocrinology Diabetes and Metabolism Osteoporosis Inflammation Article 03 medical and health sciences 0302 clinical medicine BMD Internal medicine medicine Orthopedics and Sports Medicine Femur Microarchitecture Femoral neck Bone mineral business.industry IMO medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology Cortical bone Secondary osteoporosis lcsh:RC925-935 medicine.symptom business P2X7 Glucocorticoid 030215 immunology medicine.drug |
| Zdroj: | Bone Reports, Vol 7, Iss C, Pp 145-151 (2017) Kvist, T M, Syberg, S, Petersen, S, Ding, M, Jørgensen, N R & Schwarz, P 2017, ' The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis ', Bone Reports, vol. 7, pp. 145-151 . https://doi.org/10.1016/j.bonr.2015.09.003 Bone Reports Kvist, T M, Syberg, S, Petersen, S, Ding, M, Rye Jørgensen, N & Schwarz, P 2017, ' The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis ', Bone Reports, vol. 7, pp. 145-151 . https://doi.org/10.1016/j.bonr.2015.09.003 |
| ISSN: | 2352-1872 |
| DOI: | 10.1016/j.bonr.2015.09.003 |
| Popis: | In inflammatory autoimmune diseases, bone loss is frequent. In most cases, secondary osteoporosis is caused by treatment with systemic glucocorticoid. However, the pathogenesis behind the bone loss is presumed multifactorial. We aimed to elucidate the role of the P2X7 receptor on bone mineral density (BMD), microarchitecture, and bone strength in a standardized mouse model of inflammation-mediated osteoporosis (IMO). In total 146 mice completed our protocol, 70 wild type (WT) mice and 76 P2X7 −/− (knockout, KO). BMD at the femur and spine decreased significantly from baseline to day 20 in the WT IMO mice (p Highlights • We aimed to elucidate the role of the P2X7 receptor on BMD, microarchitecture, and bone strength in a model of Inflammation-Mediated Osteoporosis • WT and P2X7knockout mice were investigated. BMD at the femur and spine decreased significantly from baseline to day 20 in the WT IMO mice (p |
| Databáze: | OpenAIRE |
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