Evaluating the role of curcum powder as a protective factor against bladder cancer--an experimental study
| Autor: | Hala O. El-Mesallamy, Abeer M Ashmawey, Nada Osama, Tarek M Salman |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research Antioxidant Epidemiology medicine.medical_treatment Urinary Bladder Pharmacology medicine.disease_cause Butylamines chemistry.chemical_compound Curcuma medicine Escherichia coli Animals Interleukin 6 Escherichia coli Infections Bladder cancer Urinary bladder Nitrates biology business.industry Interleukin-6 Public Health Environmental and Occupational Health NF-kappa B Cancer Antimicrobial medicine.disease Diet Rats medicine.anatomical_structure Oncology chemistry Proto-Oncogene Proteins c-bcl-2 Urinary Bladder Neoplasms Nitrosamine Immunology biology.protein Carcinogens business |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(10) |
| ISSN: | 2476-762X |
| Popis: | Throughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium nitrate (NaNO3); and infected with Escherichia coli (E. coli) and also to monitor changes in nuclear factor the Kappa B p65 (NF-κB p56) pathway and its downstream products, Bcl-2 and interleukin-6 (IL-6), in parallel with nitrosamine precursors, E. coli and curcum treatment. Rats were divided into three groups (n=25 each; except of control group, n+20). Group I a normal control group, group II administered DBA/NaNO3 in drinking water and infected with E. coli and group III was administered DBA/NaNO3 in drinking water, infected with E. coli and receiving standard diet containing 1% curcum powder. Histopathological examination reflected that the curcum treated group featured a lower incidence of urinary bladder lesions,and lower levels of NF-κB, Bcl-2 and IL-6, than the group receiving nitrosamine precursor and infected with E. coli. These findings suggested that curcum may have a protective role during the process of bladder carcinogenesis by inhibiting the NF-κB pathway and its downstream products. |
| Databáze: | OpenAIRE |
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