Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT
| Autor: | Long Yu Yeung, Nithin Manohar Rayudu, Maximilian T. Löffler, Jan S. Kirschke, Anjany Sekuboyina, Nico Sollmann, Thomas Baum, Egon Burian, Karupppasamy Subburaj, Tobias Greve, Michael Dieckmeyer |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
Finite-Elemente-Methode incidental vertebral fracture Clinical Biochemistry Osteoporosis 030209 endocrinology & metabolism Computed tomography multidetector computed tomography Lumbar vertebrae finite element analysis spine Wirbelbruch Article 030218 nuclear medicine & medical imaging Multidetector computed tomography osteoporosis 03 medical and health sciences 0302 clinical medicine medicine ddc:610 Osteoporose Bone mineral lcsh:R5-920 Receiver operating characteristic medicine.diagnostic_test business.industry Finite element analysis Area under the curve Mean age Spinal fractures medicine.disease Spine medicine.anatomical_structure lcsh:Medicine (General) Nuclear medicine business DDC 610 / Medicine & health Mehrzeilendetektorcomputertomographie |
| Zdroj: | Diagnostics Diagnostics; Volume 11; Issue 2; Pages: 208 Diagnostics, Vol 11, Iss 208, p 208 (2021) |
| ISSN: | 2075-4418 |
| Popis: | To investigate whether finite element (FE) analysis of the spine in routine thoracic/abdominal multi-detector computed tomography (MDCT) can predict incidental osteoporotic fractures at vertebral-specific level; Baseline routine thoracic/abdominal MDCT scans of 16 subjects (8(m), mean age: 66.1 ± 8.2 years and 8(f), mean age: 64.3 ± 9.5 years) who sustained incidental osteoporotic vertebral fractures as confirmed in follow-up MDCTs were included in the current study. Thoracic and lumbar vertebrae (T5-L5) were automatically segmented, and bone mineral density (BMD), finite element (FE)-based failure-load, and failure-displacement were determined. These values of individual vertebrae were normalized globally (g), by dividing the absolute value with the average of L1-3 and locally by dividing the absolute value with the average of T5-12 and L1-5 for thoracic and lumbar vertebrae, respectively. Mean-BMD of L1-3 was determined as reference. Receiver operating characteristics (ROC) and area under the curve (AUC) were calculated for different normalized FE (Kload, Kdisplacement,K(load)g, and K(displacement)g) and BMD (KBMD, and K(BMD)g) ratio parameter combinations for identifying incidental fractures. Kload, K(load)g, KBMD, and K(BMD)g showed significantly higher discriminative power compared to standard mean BMD of L1-3 (BMDStandard) (AUC = 0.67 for Kload; 0.64 for K(load)g; 0.64 for KBMD; 0.61 for K(BMD)g vs. 0.54 for BMDStandard). The combination of Kload, Kdisplacement, and KBMD increased the AUC further up to 0.77 (p < 0.001). The combination of FE with BMD measurements derived from routine thoracic/abdominal MDCT allowed an improved prediction of incidental fractures at vertebral-specific level. publishedVersion |
| Databáze: | OpenAIRE |
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