2-deoxy-d-glucose antinociception and serotonin receptor subtype antagonists: Test-specific effects in rats
| Autor: | Michelle C. Fisher, Richard J. Bodnar |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Indoles Tropisetron Clinical Biochemistry Methysergide Ritanserin Deoxyglucose Pharmacology Toxicology Serotonergic Biochemistry Rats Sprague-Dawley Behavioral Neuroscience Internal medicine Reaction Time medicine Animals Biological Psychiatry 5-HT receptor Endogenous opioid Analgesics Dose-Response Relationship Drug Chemistry Histaminergic Rats Endocrinology Mechanism of action Serotonin Antagonists Serotonin medicine.symptom medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 43:1241-1246 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(92)90509-e |
| Popis: | The antinociceptive actions of 2-deoxy- d -glucose (2-DG) are mediated in part by endogenous opioid, dopaminergic, cholinergic, histaminergic, and neuro-hormonal influences. Although 2-DG antinociception was not affected by tryptophan hydroxylase inhibition, a possible serotonergic role in 2-DG antinociception was investigated because of the existence of serotonin [5-hydroxytryptamine (5-HT)] receptor subtypes. The present study examined the effects of general (methysergide: 5 and 10 mg/kg), 5-HT 2 (ritanserin: 2.5 mg/kg), and 5-HT 3 (ICS-205,930: 0.25–5 mg/kg) receptor subtype antagonists upon 2-DG antinociception on the tail-flick and jump tests in rats. On the tail-flick test, 2-DG (450 mg/kg) antinociception was significantly reduced by all ICS-205,930 doses (48–58%) but unaffected by either methysergide (22–29% reduction) or ritanserin (6% reduction). In contrast, 2-DG antinociception on the jump test was significantly potentiated across the 120-min time course and across the 2-DG dose-response curve (100–650 mg/kg) by methysergide, ritanserin, and ICS-205,930 pretreatment. Each of the three antagonists produced significant leftward shifts in the peak and total 2-DG dose-response curve for the jump test. These data suggest different sites of action for 2-DG antinociception as a function of the pain test employed and a differential modulation by serotonin receptor subtypes at those sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|