Role of L-arginine/nitric oxide pathway in the antinociceptive activities of morphine and mepyramine in mice
| Autor: | Iclal Cakici, Bahar Tunctan, Ilker Kanzik, Nurettin Abacioglu, Rüya Güzel Özmen |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Arginine medicine.drug_class Analgesic Mepyramine Pharmacology Nitric Oxide Nitric oxide chemistry.chemical_compound Mice Drug Discovery Abdomen medicine Benzoquinones Animals Drug Interactions Enzyme Inhibitors Pain Measurement Pyrilamine omega-N-Methylarginine biology Morphine Chemistry Receptor antagonist Nitric oxide synthase Analgesics Opioid Nociception biology.protein Histamine H1 Antagonists Nitric Oxide Synthase medicine.drug Muscle Contraction Signal Transduction |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0004-4172 |
| Popis: | The p-benzoquinone (PBQ) -induced abdominal constriction test was used to assess the involvement of L-arginine/nitric oxide (NO) pathway in the antinociceptive activity of the subcutaneously administered H 1 -receptor antagonist, mepyramine (CAS 59-33-6), and an opioid receptor agonist, morphine (CAS 57-27-2), in mice. Mepyramine (ED 50 : 5.6 mg/kg) and morphine (ED 50 : 0.13 mg/kg) produced antinociceptive effects. The NO precursor L-arginine (CAS 1119-34-2) (50 mg/kg) also produced antinociception similar to mepyramine, but significantly less than morphine. The NO synthase (NOS) inhibitor L-N G -monomethylarginine (L-NMMA) (CAS 53308-83-1) (50 mg/ kg) did not significantly change p-benzoquinone-induced abdominal constrictions. L-arginine significantly increased the antinociceptive effects of morphine and mepyramine. The antinociceptive activity of morphine, but not that of mepyramine, was completely abolished when combined with L-NMMA. L-NMMA also significantly decreased the antinociception induced by morphine or mepyramine in combination with L-arginine. The present results suggest that morphine and mepyramine could produce peripheral antinociception by the involvement of L-arginine/NO cascade or other related pathways of nociceptive processes induced by NO. |
| Databáze: | OpenAIRE |
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