Variceal Bleed and Portal Hypertensive Gastropathy in a Noncirrhotic Patient with Isolated Splenomegaly
| Autor: | Jennifer Leonard, S. M. Mahmudul Hasan, Meghan Dmitriew |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry medicine.medical_treatment Case Report Portal hypertensive gastropathy General Medicine RC799-869 Diseases of the digestive system. Gastroenterology medicine.disease Gastroenterology Pancytopenia 03 medical and health sciences Liver disease 0302 clinical medicine Esophageal varices 030220 oncology & carcinogenesis Internal medicine medicine Portal hypertension 030211 gastroenterology & hepatology business Varices Transjugular intrahepatic portosystemic shunt |
| Zdroj: | Case Reports in Hepatology, Vol 2020 (2020) Case Reports in Hepatology |
| ISSN: | 2090-6595 2090-6587 |
| Popis: | Portal hypertension caused by cirrhosis is the most common etiology of esophageal varices. However, abnormalities of the splenoportal axis in the absence of liver disease may also cause portal hypertension resulting in varices. We report a rare case of esophageal variceal bleed in a noncirrhotic patient with isolated splenomegaly secondary to chronic granulocyte colony stimulating factor (G-CSF) therapy. The patient is a 26-year-old male with Cohen syndrome who required long-term G-CSF treatment for chronic neutropenia. He presented with large volume hematemesis and pancytopenia in the setting of known splenomegaly with no evidence of cirrhosis. An urgent EGD revealed active variceal bleeding and portal hypertensive gastropathy. The patient was appropriately resuscitated and underwent a successful transjugular intrahepatic portosystemic shunt and CT-guided coil placement for the bleeding varices. We are the first to report variceal bleed as a complication of long-term G-CSF use, a life-threatening consequence that requires urgent intervention. |
| Databáze: | OpenAIRE |
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