Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [(18)F]FPEB PET
| Autor: | Nicole DellaGioia, Nabeel Nabulsi, Adam P. Mecca, Julia W. McDonald, David Matuskey, Yiyun Huang, Ansel T. Hillmer, Jim Ropchan, Richard E. Carson, Wenzhen Zhao, Zachary Jacobs, Christopher H. van Dyck, Hannah R. Michalak, Irina Esterlis, Kelly Rogers, Keunpoong Lim |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Fluorine Radioisotopes Partial volume Hippocampus 0302 clinical medicine Cortex (anatomy) [18F]FPEB PET Gray Matter mGluR5 Aged 80 and over medicine.diagnostic_test Metabotropic glutamate receptor 5 05 social sciences Glutamate receptor Organ Size Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Neurology Positron emission tomography Female RC321-571 Adult medicine.medical_specialty Adolescent Cognitive Neuroscience Receptor Metabotropic Glutamate 5 Neurosciences. Biological psychiatry. Neuropsychiatry Neuroimaging 050105 experimental psychology Article 03 medical and health sciences Glutamatergic Young Adult Fluorodeoxyglucose F18 Internal medicine medicine Humans 0501 psychology and cognitive sciences Aged Brain Chemistry business.industry Endocrinology Metabotropic glutamate receptor Positron-Emission Tomography Radiopharmaceuticals business 030217 neurology & neurosurgery |
| Zdroj: | Neuroimage NeuroImage, Vol 238, Iss, Pp 118217-(2021) |
| Popis: | Objective Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability. Methods Cognitively normal participants (n = 45), aged 18 to 84 years, underwent [18F]FPEB positron emission tomography scans to quantify brain mGluR5. Distribution volume (VT) was computed using a venous or arterial input function and equilibrium modeling from 90 to 120 minutes. In the primary analysis, the association between age and VT in the hippocampus and association cortex was evaluated using a linear mixed model. Exploratory analyses assessed the association between age and VT in multiple brain regions. The contribution of gray matter tissue alterations and partial volume effects to associations with age was also examined. Results In the primary analysis, older age was associated with lower [18F]FPEB binding to mGluR5 (P = 0.026), whereas this association was not significant after gray matter masking or partial volume correction to account for age-related tissue loss. Post hoc analyses revealed an age-related decline in mGluR5 availability in the hippocampus of 4.5% per decade (P = 0.007) and a non-significant trend in the association cortex (P = 0.085). An exploratory analysis of multiple brain regions revealed broader inverse associations of age with mGluR5 availability, but not after partial volume correction. Conclusion Reductions in mGluR5 availability with age appear to be largely mediated by tissue loss. Quantification of [18F]FPEB binding to mGluR5 may expand our understanding of age-related molecular changes and the relationship with brain tissue loss. |
| Databáze: | OpenAIRE |
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