A revised estimate of twin concordance in systemic lupus erythematosus
| Autor: | David A. Horwitz, Pradip Roy-Burman, Barbara Bachman, Ann Walker, Lisa Weinrib, Thomas M. Mack, Agustin Escalante, Dennis Deapen |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Adolescent Zygote Concordance Immunology Disease Rheumatology Internal medicine medicine Diseases in Twins Immunology and Allergy Humans Lupus Erythematosus Systemic Pharmacology (medical) skin and connective tissue diseases Child Aged Lupus erythematosus business.industry Incidence (epidemiology) Incidence Middle Aged medicine.disease Dermatology Zygosity DNA profiling Female business |
| Zdroj: | Arthritis and rheumatism. 35(3) |
| ISSN: | 0004-3591 |
| Popis: | Objective. Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage. Methods. We established a registry of twins with SLE, based upon self-reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins. Results. Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self-described MZ twins and 7 self-described DZ twins. AH individuals had correctly predicted their zygosity. Conclusion. MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed. |
| Databáze: | OpenAIRE |
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