Assessment of the FAM174A 11G allele as a risk allele for equine metabolic syndrome
| Autor: | Aaron Rendahl, E. M. Norton, Dianne McFarlane, Nichol Schultz, James R. Mickelson, M. M. Roy, Raymond J. Geor, Molly E. McCue |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Population Biology Foot Diseases 03 medical and health sciences Insulin resistance Risk Factors Internal medicine Genotype Genetics medicine Animals Horses Allele education Allele frequency Alleles Metabolic Syndrome education.field_of_study Adiponectin 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine Laminitis medicine.disease 040201 dairy & animal science 030104 developmental biology Endocrinology Equine metabolic syndrome Animal Science and Zoology Female Horse Diseases |
| Zdroj: | Animal geneticsReferences. 51(4) |
| ISSN: | 1365-2052 |
| Popis: | An 11G nucleotide repeat in the 3' UTR of FAM174A was recently postulated as a risk allele with a dominant mode of inheritance for equine metabolic syndrome (EMS) and laminitis status in Arabian horses. The objective of this project was to evaluate this hypothesis in a large and diverse across-breed population. A total of 301 ponies, 292 Morgans, 64 Arabians, 49 Tennessee Walking Horses and 59 Quarter Horses were genotyped for six observed G repeat alleles in the FAM174A 3' UTR. Phenotype data included laminitis status, baseline insulin, glucose, non-esterified fatty acids, triglycerides, adiponectin, leptin, ACTH, insulin and glucose post oral sugar test, and two proxies for insulin resistance. The 11G allele frequencies were 18.8, 6.9, 1.8, 0.2 and 0.0% in the Arabians, Tennessee Walkers, ponies, Morgans and Quarter Horses respectively. Association analyses between FAM174A genotype and EMS phenotypes, and between allele count and EMS phenotypes, identified no statistically significant associations. When a dominant effect for the 11G allele was evaluated, a statistically significant association with adiponectin levels was identified in the ponies, and pairwise comparisons revealed that the estimated marginal means were higher in ponies with the 11G allele vs. alternative alleles (i.e. the allele had a protective effect). In conclusion, our data do not support the FAM174A 11G allele as a risk allele for EMS in our studied breeds. |
| Databáze: | OpenAIRE |
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