Tenofovir-induced Stevens-Johnson syndrome in a patient with acute hepatitis B: A rare case report
| Autor: | Dilip Chandrasekhar, Muhammed Hashik Pk, Rahana K, P R Athira, Saju Xavier, Abel C. Mathew, Hathim Basheer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Tenofovir Pharmacology (nursing) Pharmacy 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Swallowing Rare case medicine Humans 030212 general & internal medicine Pharmacology business.industry virus diseases Middle Aged Jaundice Hepatitis B medicine.disease Rash Dermatology stomatognathic diseases Stevens-Johnson Syndrome Female Acute hepatitis B medicine.symptom business Adverse drug reaction medicine.drug |
| Zdroj: | Journal of the American Pharmacists Association. 60:e365-e369 |
| ISSN: | 1544-3191 |
| DOI: | 10.1016/j.japh.2020.06.029 |
| Popis: | Objective To report a rare case of a hepatitis B patient who developed the Stevens-Johnson syndrome (SJS) secondary to tenofovir use. Case summary A 61-year-old woman presented with complaints of jaundice, difficulty in swallowing, and burning sensation all over the body along with erythematous polymorphic rash on the face, upper limbs, and trunk. She was diagnosed with SJS secondary to tenofovir. The causality of adverse drug reaction was assessed using the World Health Organization—Uppsala Monitoring Centre causality scale, and adverse drug reaction was found to be probable. Tenofovir was withdrawn and the patient was conservatively managed. Practice implications Through the observation of this event, we could figure out the association between tenofovir and SJS. Prompt withdrawal of the offending agent and the initiation of therapy with systemic corticosteroids and supportive medication were found to be effective. |
| Databáze: | OpenAIRE |
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