Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible
| Autor: | Iola F. Duarte, Sofia Dembski, Patricia M. A. Farias, Despina Fragouli, Winfried Neuhaus, Andreas Brachner, Manosij Ghosh, Jeroen Vanoirbeek, Daniela Zdzieblo, Ivan Barišić, Philipp Schwabl |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
IMPACTS
Microplastics Aquatic Organisms microplastics Health Toxicology and Mutagenesis Plastic materials lcsh:Medicine Environmental Sciences & Ecology 02 engineering and technology human exposure 010501 environmental sciences METABOLISM 01 natural sciences biofilm NANOPLASTICS Aquatic organisms CHEMICALS Human health Health hazard neurotoxicity Humans ddc:610 0105 earth and related environmental sciences Public Environmental & Occupational Health microparticles Science & Technology biological barriers Biological modeling microbe carrier Communication lcsh:R Public Health Environmental and Occupational Health toxicity 021001 nanoscience & nanotechnology BARRIER MICROBIOTA nanoplastics Human exposure Environmental science Polystyrenes nanoparticles Biochemical engineering 0210 nano-technology Risk assessment Plastics Life Sciences & Biomedicine Water Pollutants Chemical Environmental Sciences |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 8832, p 8832 (2020) International Journal of Environmental Research and Public Health |
| Popis: | The exposure of humans to nano-and microplastic particles (NMPs) is an issue recognized as a potential health hazard by scientists, authorities, politics, non-governmental organizations and the general public. The concentration of NMPs in the environment is increasing concomitantly with global plastic production and the usage of plastic materials. NMPs are detectable in numerous aquatic organisms and also in human samples, therefore necessitating a risk assessment of NMPs for human health. So far, a comprehensive risk assessment of NMPs is hampered by limited availability of appropriate reference materials, analytical obstacles and a lack of definitions and standardized study designs. Most studies conducted so far used polystyrene (PS) spheres as a matter of availability, although this polymer type accounts for only about 7% of total plastic production. Differently sized particles, different concentration and incubation times, and various biological models have been used, yielding hardly comparable data sets. Crucial physico-chemical properties of NMPs such as surface (charge, polarity, chemical reactivity), supplemented additives and adsorbed chemicals have been widely excluded from studies, although in particular the surface of NMPs determines the interaction with cellular membranes. In this manuscript we give an overview about the critical parameters which should be considered when performing risk assessments of NMPs, including novel reference materials, taking into account surface modifications (e.g., reflecting weathering processes), and the possible role of NMPs as a substrate and/or carrier for (pathogenic) microbes. Moreover, we make suggestions for biological model systems to evaluate immediate toxicity, long-term effects and the potential of NMPs to cross biological barriers. We are convinced that standardized reference materials and experimental parameters along with technical innovations in (nano)-particle sampling and analytics are a prerequisite for the successful realization of conclusive human health risk assessments of NMPs. ispartof: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH vol:17 issue:23 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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