Antidepressant medication use, depression, and the risk of preeclampsia
| Autor: | De-Kun Li, Hong Y. Chen, Lyndsay A. Avalos |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Serotonin reuptake inhibitor Population Antidepressive Agents Tricyclic Article Preeclampsia Pre-Eclampsia Pregnancy Risk Factors Internal medicine Humans Medicine education Depression (differential diagnoses) education.field_of_study Depression business.industry medicine.disease Pregnancy Complications Psychiatry and Mental health Relative risk Antidepressive Agents Second-Generation Antidepressant Female Neurology (clinical) business Reuptake inhibitor Cohort study |
| Zdroj: | CNS Spectrums. 20:39-47 |
| ISSN: | 2165-6509 1092-8529 |
| DOI: | 10.1017/s1092852915000024 |
| Popis: | ObjectiveTo assess the effects of depression and antidepressant medication use during pregnancy on the risk of preeclampsia.MethodsWe conducted a retrospective, population-based cohort study that linked automated clinical and pharmacy databases including comprehensive electronic medical records of 21,589 pregnant Kaiser Permanente Northern California members between 2010 and 2012.ResultsThe overall risk of preeclampsia was 4.5%. The timing of antidepressant medication exposure was an important factor. A significant increase in the risk of preeclampsia emerged for women with a depression diagnosis who took antidepressant medications during the second trimester compared to women with untreated depression (adjusted relative risk [aRR]: 1.6, 95% CI: 1.06, 2.39) and to women without depression (aRR: 1.70, 95% CI: 1.30, 2.23). Similar associations existed for women who took antidepressant medications, but without depression. In contrast, depressed women with psychotherapy showed no increased risk of preeclampsia compared to women with untreated depression or no depression. There was also a statistically significant relationship between the duration of antidepressant medication use and preeclampsia. The observed association appeared stronger for selective serotonin reuptake inhibitor (SSRI) use, although a nonsignificant trend was also noted for use of norepinephrine-dopamine reuptake inhibitors (NDRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).ConclusionStudy findings suggest that antidepressant use during pregnancy may increase the risk of preeclampsia, especially use during the second trimester. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|