Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±)-Flustramide B
| Autor: | Kui Wu, Ting Wang, Yuliu Du |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Indole test 010405 organic chemistry Alkene Organic Chemistry Substrate (chemistry) chemistry.chemical_element Aromaticity 010402 general chemistry Photochemistry 01 natural sciences Biochemistry Radical cyclization 0104 chemical sciences chemistry Cascade Physical and Theoretical Chemistry Carbon Visible spectrum |
| Zdroj: | Organic letters. 19(20) |
| ISSN: | 1523-7052 |
| Popis: | The development of visible-light-mediated synthesis of pyrroloindolines via an amidyl radical cyclization–carbon radical functionalization cascade is reported. The transformation shows a broad substrate scope, tolerating a variety of substitutions on indole aromatic rings and N-centers. Different functionalized alkene systems could be used as radical acceptors. Relying on this strategy, a rapid synthesis of flustramide B was achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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