SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents

Autor:	Liu Yang, Wen Bo Xu, Liangpeng Sun, Changhao Zhang, Cheng Hua Jin
Rok vydání:	2022
Předmět:	Pharmacology Structure-Activity Relationship Antifungal Agents Heterocyclic Compounds Organic Chemistry Drug Discovery Fungi Molecular Medicine Humans Microbial Sensitivity Tests General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	ChemMedChem. 17(12)
ISSN:	1860-7187
Popis:	Infections caused by eukaryotic organisms, such as fungi, are generally more difficult to treat than bacterial infections. With the widespread use of antifungal drugs in humans and plants, resistance and toxicity have emerged. Therefore, it is desirable to develop new antifungal drugs with low toxicity that are not susceptible to the development of resistance. This review presents a summary of the past few years (2017-2021) of research on heterocyclic compounds as antifungal agents for use in humans and plants, focusing on the structure-activity relationships (SAR) of these compounds. This review may provide ideas and information for designing and developing new antifungal drugs with fewer side effects compared with currently available drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4220d0c13d557a07489de0a7c225f5b https://pubmed.ncbi.nlm.nih.gov/35475328 Zobrazit plný text záznamu Plný text