The MDM2 SNP309T>G Polymorphism Increases Bladder Cancer Risk among Caucasians: a Meta-analysis
Autor: | Qing-Yun Wu, Xin-Sheng Peng, Hui Zhou, Huai-Gao Wang, Meng-Jie Shi, Jie-Mei Li, Yan-Fang Zhou |
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Rok vydání: | 2014 |
Předmět: |
Risk
Cancer Research medicine.medical_specialty Genotype Epidemiology Bioinformatics Polymorphism Single Nucleotide Gastroenterology White People Risk Factors Internal medicine medicine Genetic predisposition Humans Genetic Predisposition to Disease Allele Alleles Bladder cancer business.industry Public Health Environmental and Occupational Health Case-control study Proto-Oncogene Proteins c-mdm2 Odds ratio medicine.disease Confidence interval Urinary Bladder Neoplasms Oncology Case-Control Studies Meta-analysis business |
Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:5277-5281 |
ISSN: | 1513-7368 |
Popis: | Published studies have evaluated associations between the MDM2 SNP309T>G polymorphism and bladder cancer susceptibility. However, these generated inconsistent results. The aim of the present investigation was to quantify the strength of association between MDM2 SNP309T>G polymorphism and bladder cancer risk by conducting a meta-analysis. We searched PubMed and Embase for related studies that had been published in English before April 1, 2014 and associations were assessed by summarizing the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Five case-control studies with a total of 972 cases and 1,012 controls were finally identified to be eligible for the meta-analysis. Overall, the results indicated that there was no significant association between the MDM2 SNP309T>G polymorphism and bladder cancer risk (for the allele model G vs. T: OR=1.08, 95% CI 0.85-1.36, p=0.54; for the co-dominant model GG vs. TT: OR=1.20, 95% CI 0.74-1.93, p=0.46; for the dominant model GG+GT vs. TT: OR=0.98, 95% CI 0.80-1.20, p=0.83; for the recessive model GG vs. GT+TT: OR=1.20, 95% CI 0.83-1.74, p=0.33). However, on subgroup analysis by ethnicity, significant associations were found in Caucasians in three models (for the allele model G vs. T: OR=1.41, 95% CI 1.10-1.81, p=0.006; for the co-dominant model GG vs. TT: OR=2.16, 95% CI 1.28-3.63, p=0.004; for the recessive model GG vs. GT+TT: OR=2.06, 95% CI 1.31-3.22, p=0.002). In summary, the present meta-analysis provides evidence that the genotype for the MDM2 SNP309T>G polymorphism may be associated with genetic susceptibility to bladder cancer among Caucasians. |
Databáze: | OpenAIRE |
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