Partial purification of erythropoietin by alcoholic fraction
| Autor: | H. Berger, W. H. Linkenheimer, E. L. Patterson, W. C. Grant |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
Ethanol Erythrocytes medicine.diagnostic_test Chemistry Reticulocytosis Fraction (chemistry) Fractionation Hematocrit General Biochemistry Genetics and Molecular Biology Hematopoiesis Epoetin Alfa Haematopoiesis chemistry.chemical_compound Endocrinology Erythropoietin Internal medicine medicine medicine.symptom medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 107 |
| ISSN: | 0037-9727 |
| Popis: | SummaryThe erythropoietic stimulating principle present in the filtrate of plasma obtained from anemic rabbits was partially purified by ethanol fractionation. This material was active in increasing Fe50 intake of normal rats and in producing a reticulocytosis and hematocrit elevation in repeatedly injected normal rats. Fe50 uptake was stimulated by as little as 0.08 mg of the fraction representing a concentration of 3,000 fold over that occurring in the plasma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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