The Gut Mycobiome in Parkinson's Disease
| Autor: | Daniel Kliger, Kristen Sundvick, Adam C. Yu, Mihai Cirstea, Silke Appel-Cresswell, Ella Golz, Rozlyn C.T. Boutin, B. Brett Finlay |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
DNA Bacterial Male Parkinson's disease Gut–brain axis Disease Biology Environmental - origin Microbiology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Humans Microbiome Internal transcribed spacer DNA Fungal Aged High-Throughput Nucleotide Sequencing Parkinson Disease Sequence Analysis DNA Middle Aged medicine.disease Gut microbiome Gastrointestinal Microbiome 030104 developmental biology Cross-Sectional Studies Female Neurology (clinical) 030217 neurology & neurosurgery Mycobiome |
| Zdroj: | Journal of Parkinson's disease. 11(1) |
| ISSN: | 1877-718X |
| Popis: | The gut microbiome has been increasingly implicated in Parkinson’s disease (PD); however, most existing studies employ bacterial-specific sequencing, and have not investigated non-bacterial microbiome constituents. Here, we use fungal-specific internal transcribed spacer (ITS)-2 amplicon sequencing in a cross-sectional PD cohort to investigate associations between the fungal gut microbiome and PD. Fungal load among participants was extremely low, and genera identified were almost exclusively of proposed dietary or environmental origin. We observed significantly lower fungal DNA relative to bacterial DNA among PD patients. No fungi differed in abundance between patients and controls, nor were any associated with motor, cognitive, or gastrointestinal features among patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|