The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation
| Autor: | Horvitz Hr, Bloom L |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
DNA
Complementary Protein family Molecular Sequence Data Biology medicine Gene family Animals Humans Amino Acid Sequence Axon Cloning Molecular Caenorhabditis elegans Caenorhabditis elegans Proteins Peptide sequence Gene Genetics Multidisciplinary Sequence Homology Amino Acid fungi Neuropeptides Biological Sciences biology.organism_classification Axons medicine.anatomical_structure nervous system Multigene Family FEZ1 Intracellular |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 94(7) |
| ISSN: | 0027-8424 |
| Popis: | The gene unc-76 ( unc , uncoordinated) is necessary for normal axonal bundling and elongation within axon bundles in the nematode Caenorhabditis elegans . The UNC-76 protein and two human homologs identified as expressed sequence tags are not similar to previously characterized proteins and thus represent a new protein family. At least one of these human homologs can function in C. elegans , suggesting that it, like UNC-76, acts in axonal outgrowth. We propose that the UNC-76 protein, which is found in cell bodies and processes of all neurons throughout development, either has a structural role in the formation and maintenance of axonal bundles or transduces signals to the intracellular machinery that regulates axonal extension and adhesion. |
| Databáze: | OpenAIRE |
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