Total synthesis of cryptophycin analogues via a scaffold approach
| Autor: | McCubbin Ja, Matthew L. Maddess, Mark Lautens |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Aldehydes
Vinyl Compounds Esterification Molecular Structure Stereochemistry Chemistry Organic Chemistry Molecular Conformation Total synthesis Stereoisomerism Antimitotic Agents Metathesis Crystallography X-Ray Biochemistry Combinatorial chemistry Peptides Cyclic chemistry.chemical_compound Vinyl halide Cryptophycin Depsipeptides Antimitotic Agent Physical and Theoretical Chemistry Derivatization Cryptophycins |
| Zdroj: | Organic letters. 8(14) |
| ISSN: | 1523-7060 |
| Popis: | [reaction: see text] Allylation of in situ generated beta,gamma-unsaturated aldehydes affords rapid access to vinyl halide analogues of fragment A of the cryptophycins. Three scaffolds are prepared in gram quantities by a ring-closing metathesis approach. Derivatization via a variety of cross-coupling protocols is possible, which affords novel analogues of these potent antimitotic agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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