Platelet-Activating Factor (PAF) Receptor Binding Antagonist Activity of the Methanol Extracts and Isolated Flavonoids from Chromolaena odorata (L.) KING and ROBINSON
| Autor: | Sui Kiong Ling, Salbiah Man, Mazura M. D. Pisar |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Blood Platelets
Naringenin Stereochemistry Chromolaena odorata Pharmaceutical Science Ether Platelet Membrane Glycoproteins Plant Roots Receptors G-Protein-Coupled Inhibitory Concentration 50 chemistry.chemical_compound Animals Taxifolin Dimethyl ether Flavonoids Pharmacology Chromatography Molecular Structure Plant Stems biology Plant Extracts Chromolaena Methanol food and beverages General Medicine Eriodictyol biology.organism_classification Plant Leaves chemistry Rabbits Kaempferol Quercetin |
| Zdroj: | Biological and Pharmaceutical Bulletin. 30:1150-1152 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | The leaf, stem and root extracts of Chromolaena odorata were evaluated for their effect on platelet-activating factor (PAF) receptor binding on rabbit platelets using 3H-PAF as a ligand. The leaf extract demonstrated high PAF receptor binding inhibitory activity of 79.2+/-2.1% at 18.2 microg/ml. A total of eleven flavonoids were subsequently isolated from the active leaf extract and evaluated for their effects on PAF receptor binding. Eight of the flavonoids exhibited >50% inhibition on the binding activity at 18.2 microg/ml. These flavonoids were identified as eriodictyol 7,4'-dimethyl ether, quercetin 7,4'-methyl ether, naringenin 4'-methyl ether, kaempferol 4'-methyl ether, kaempferol 3-O-rutinoside, taxifolin 4'-methyl ether, taxifolin 7-methyl ether and quercetin 4'-methyl ether. Their IC50 values ranged from 19.5 to 62.1 microM. |
| Databáze: | OpenAIRE |
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