Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep
| Autor: | Michael Kluge, Alexander Yassouridis, Axel Steiger, Verena Zuber, Petra Schüssler |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors Hydrocortisone Peptide Hormones Polysomnography Endocrinology Diabetes and Metabolism Peptide hormone Corticotropin-releasing hormone Endocrinology Reference Values Internal medicine Humans Medicine Single-Blind Method Biological Psychiatry Morning Slow-wave sleep Analysis of Variance Cross-Over Studies Endocrine and Autonomic Systems business.industry Ghrelin Growth hormone secretion Circadian Rhythm Psychiatry and Mental health Growth Hormone Sleep Stages business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 32:287-292 |
| ISSN: | 0306-4530 |
| Popis: | Ghrelin and growth hormone (GH) releasing hormone (GHRH) both stimulate GH secretion and slow wave sleep (SWS), whereas ghrelin increases, and GHRH decreases cortisol in males. However, GHRH's effect on sleep and cortisol was abolished, on GH mitigated, when administered in the early morning, possibly due to counteracting corticotropin releasing hormone (CRH). Aim of this study was to investigate ghrelin's influence on sleep, GH and cortisol when administered in the early morning. Nocturnal (2000-1000 h) GH and cortisol patterns and polysomnography (2300-1000 h) were determined in 12 healthy males (25.3+/-3.2 yr) twice, receiving 50 microg ghrelin or placebo at 0400, 0500, 0600, and 0700 h, in this single-blind, randomized, cross-over study. The first ghrelin bolus caused the strongest (38.7+/-6.5 ng/ml, placebo: 0.4+/-1.1 ng/ml), second and third smaller, the fourth no GH peak. GH levels remained significantly (p |
| Databáze: | OpenAIRE |
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