Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
| Autor: | Kyung Soo Ko, Hyeong Rok Yun, Sang Woo Ahn, Sergey A. Fedoreyev, Bomin Seol, Elena A. Vasileva, Jin Han, Hyoung Kyu Kim, Byoung Doo Rhee, Jung Eun Seol, Valentin A. Stonik, Natalia P. Mishchenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
NC/Nga mice Aquatic Organisms Erythema QH301-705.5 Anti-Inflammatory Agents Pharmaceutical Science Mice Inbred Strains medicine.disease_cause Article Proinflammatory cytokine Dermatitis Atopic Mice Edema Drug Discovery medicine Animals Biology (General) Pharmacology Toxicology and Pharmaceutics (miscellaneous) Skin Transepidermal water loss echinochrome A Epidermis (botany) integumentary system atopic dermatitis business.industry Atopic dermatitis medicine.disease Water Loss Insensible proinflammation Disease Models Animal mast cell infiltration Sea Urchins Interleukin 13 Immunology Interleukin-3 medicine.symptom business Oxidative stress Naphthoquinones |
| Zdroj: | Marine Drugs, Vol 19, Iss 622, p 622 (2021) Marine Drugs Volume 19 Issue 11 |
| ISSN: | 1660-3397 |
| Popis: | Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter® and Corneometer® measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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