Cytolytic T Lymphocytes Raised Against a Human Bladder Carcinoma Recognize an Antigen Encoded by Gene MAGE-A12
| Autor: | Leonora Heidecker, Michael Probst-Kepper, Thierry Boon, M. Guéguen, Benoît Van den Eynde, Francis Brasseur |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
endocrine system Lung Neoplasms Esophageal Neoplasms medicine.medical_treatment Immunology Antigen presentation Biology Germline Antigen Cancer immunotherapy Antigens Neoplasm Tumor Cells Cultured medicine Carcinoma Humans Immunology and Allergy Melanoma neoplasms Aged Antigen Presentation Cancer medicine.disease Peptide Fragments Clone Cells Neoplasm Proteins CTL Urinary Bladder Neoplasms Head and Neck Neoplasms Cancer research Genes Neoplasm T-Lymphocytes Cytotoxic |
| Zdroj: | The Journal of Immunology. 164:6041-6045 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.164.11.6041 |
| Popis: | Human bladder carcinoma line LB831-BLC expresses several distinct Ags that are recognized by different autologous CTL. Here, we show that one of these Ags is presented by HLA-Cw7 and encoded by gene MAGE-A12. This is the first time that CTL directed against a MAGE-encoded Ag have been derived from the lymphocytes of a patient with cancer other than melanoma. This new Ag was found to be nonapeptide VRIGHLYIL, corresponding to position 170–178 of the MAGE-A12 protein. Gene MAGE-A12 is silent in normal tissues except in male germline cells, which do not express HLA molecules. It is expressed in 26–62% of melanomas, infiltrating bladder carcinomas, lung carcinomas, esophageal carcinomas, and head and neck carcinomas. Because HLA-Cw7 is present in 43% of Caucasians, this new Ag is shared by many tumors and should be a useful target for cancer immunotherapy. |
| Databáze: | OpenAIRE |
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