Immunistochemical Analysis of the Expression of TGFβ, Galectin-1, Vimentin, and Thrombospondin in Gastric Cancer Associated with Systemic Undifferentiated Connective Tissue Dysplasia
Autor: | M G Klinnikova, L A Naumova, O N Osipova |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Epithelial-Mesenchymal Transition Galectin 1 Gene Expression Vimentin General Biochemistry Genetics and Molecular Biology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Transforming Growth Factor beta Gastric mucosa Biomarkers Tumor Medicine Humans Undifferentiated Connective Tissue Diseases Cytoskeleton Aged Thrombospondin biology business.industry Cancer General Medicine Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Gastric Mucosa Galectin-1 biology.protein Female business Thrombospondins 030217 neurology & neurosurgery |
Zdroj: | Bulletin of experimental biology and medicine. 166(6) |
ISSN: | 1573-8221 |
Popis: | We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connective tissue dysplasia, a higher level of expression of TGFβ, galectin-1, vimentin, and thrombospondin in the tumor was detected in comparison with the perifocal and tumor zones in intestinal gastric cancer, which may reflect the pathogenetic peculiarities of the two histotypes of gastric cancer. Intestinal type of gastric cancer associated with connective tissue dysplasia is characterized by a high level of expression of galectin-1 and vimentin in the perifocal zone and TGFβ in the tumor zone. The pattern of expression of the studied markers can reflect both the pathogenetic peculiarities of the two histotypes of gastric cancer and peculiar expression of some growth factors, cytoskeleton proteins, and matrix-cell proteins associated with undifferentiated connective tissue dysplasia which may contribute to epithelial-mesenchymal transition. |
Databáze: | OpenAIRE |
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