Breast cancer radiotherapy: What physicians need to know in the era of the precision medicine

Autor: Felipe Couñago Lorenzo, Ana Aurora Díaz-Gavela, David Sanz Rosa, Luis Leonardo Guerrero, Elia del Cerro Peñalver, Sofía Sanchez García
Rok vydání: 2021
Předmět:
Zdroj: Breast Disease. 40:1-16
ISSN: 1558-1551
0888-6008
DOI: 10.3233/bd-201022
Popis: Breast cancer is the most common cancer in women worldwide and encompasses a broad spectrum of diseases in one with significant epidemiological, clinical, and biological heterogeneity, which determines a different natural history and prognostic profile. Although classical tumour staging (TNM) still provides valuable information, the current reality is that the clinicians must consider other biological and molecular factors that directly influence treatment decision-making. The management of breast cancer has changed radically in the last 15 years due to significant advances in our understanding of these tumours. This knowledge has brought with it a major impact regarding surgical and systemic management and has been practice-changing, but it has also created significant uncertainties regarding how best integrate the radiotherapy treatment into the therapeutic scheme. In parallel, radiotherapy itself has also experienced major advances, new radiobiological concepts have emerged, and genomic data and other patient-specific factors must now be integrated into individualised treatment approaches. In this context, “precision medicine” seeks to provide an answer to these open questions and uncertainties. The aim of the present review is to clarify the meaning of this term and to critically evaluate its role and impact on contemporary breast cancer radiotherapy. Sin financiación No data JCR 2021 0.269 SJR (2021) Q3, 1780/2489 Medicine (miscellaneous) No data IDR 2021 UEM
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje