Exercise and sports participation in patients with thoracic aortic disease: a review
| Autor: | M. Mostafa Mokhles, Jolien W. Roos-Hesselink, Carlijn G.E. Thijssen, Roland R.J. van Kimmenade, Antonio Pelliccia, Arjen L. Gökalp, Johanna J.M. Takkenberg, Lidia R. Bons |
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| Přispěvatelé: | Cardiology, Cardiothoracic Surgery |
| Rok vydání: | 2019 |
| Předmět: |
Marfan syndrome
medicine.medical_specialty Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Aortic Diseases Aorta Thoracic Dissection (medical) 030204 cardiovascular system & hematology Risk Assessment Mice 03 medical and health sciences 0302 clinical medicine Bicuspid aortic valve Internal medicine Internal Medicine Animals Humans Medicine In patient 030212 general & internal medicine Thoracic aortic disease Exercise biology business.industry Athletes General Medicine medicine.disease biology.organism_classification Disease Models Animal Cardiology cardiovascular system Thoracic aortic dissection Cardiology and Cardiovascular Medicine business Sports |
| Zdroj: | Expert Review of Cardiovascular Therapy, 17(4), 251-266. Taylor & Francis Ltd Expert Review of Cardiovascular Therapy, 17, 4, pp. 251-266 Expert Review of Cardiovascular Therapy, 17, 251-266 |
| ISSN: | 1744-8344 1477-9072 |
| Popis: | Introduction: Current guidelines recommend patients with thoracic aortic disease (TAD) including inherited aortopathies to avoid heavy exercise. However, evidence supporting the negative advice on exercise is scarce. We aimed to provide an up-to-date systematic review of the available evidence on risks and benefits of exercise and sports participation in TAD patients. Areas covered: A systematic search was performed in Medline, Embase and Web of Science: thoracic aortic aneurysm or thoracic aortic dissection or inheritable aortopathies including Marfan Syndrome (MFS), Loeys-Dietz syndrome, Turner Syndrome, Ehlers-Danlos syndrome, bicuspid aortic valve (BAV) and sports, exercise or athletes. The resulting 1,652 manuscripts were reviewed by two independent observers. Eventually, 26 studies and 12 case-reports were included, reporting on thoracic aortic dimensions in athletes, exercise related acute aortic dissections, and exercise in BAV and MFS patients. Expert opinion: Blood pressure elevation during exercise may be associated with an increased risk of acute aortic dissection; however, no controlled trials have longitudinally evaluated the effect of exercise on survival or the risk of aortic dissection in TAD patients. Mouse-model studies suggest beneficial effects of exercise in the setting of a dilated aorta in MFS. There is a clear need for prospective research in this field. |
| Databáze: | OpenAIRE |
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