High predicted strain coverage by the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland

Autor: Rosita De Paola, Eva Hong, Monica Moschioni, Izabela Waśko, Anna Skoczyńska, Muhamed-Kheir Taha, Maria Stella
Přispěvatelé: National Reference Centre for Bacterial Meningitis [Warsaw, Poland] (NRCBM), National Medicines Institute - Narodowy Instytut Leków [Warsaw] (NIL), Infections Bactériennes Invasives, Institut Pasteur [Paris] (IP), Novartis Vaccines and Diagnostics [Siena], The study was partially supported by the Ministry of Health within the framework of the National Programme for Antibiotic Protection (MODUL I NPOA), by the Ministry of Science and Higher Education (Mikrobank 2 Programme) and by the Polish National Science Centre grant to IW (NZ7/04315)., Institut Pasteur [Paris]
Rok vydání: 2015
Předmět:
0301 basic medicine
Vaccine coverage
MESH: Adhesins
Bacterial
4CMenB vaccine
Neisseria meningitidis
Serogroup B
medicine.disease_cause
MESH: Meningococcal Infections
MESH: Meningococcal Vaccines
MESH: Child
Child
MESH: Bacterial Proteins
Strain (chemistry)
Meningococcal disease
Neisseria meningitidis
MESH: Infant
Newborn
MESH: Enzyme-Linked Immunosorbent Assay
MESH: Infant
3. Good health
Bacterial Typing Techniques
Infectious Diseases
MESH: Multilocus Sequence Typing
MESH: Poland
MESH: Young Adult
Child
Preschool
Molecular Medicine
Adult
Adolescent
030106 microbiology
Porins
Enzyme-Linked Immunosorbent Assay
Meningococcal Vaccines
Meningococcal vaccine
Biology
Serogroup
MESH: Bacterial Typing Techniques
Microbiology
03 medical and health sciences
Young Adult
Antigen
Bacterial Proteins
MESH: Neisseria meningitidis
Serogroup B
medicine
Humans
Typing
Adhesins
Bacterial
MESH: Adolescent
Antigens
Bacterial
MESH: Porins
MESH: Humans
General Veterinary
General Immunology and Microbiology
MESH: Child
Preschool
Public Health
Environmental and Occupational Health
Infant
Newborn
Infant
MESH: Adult
MATS
MESH: Serogroup
medicine.disease
Virology
Bacterial adhesin
Meningococcal Infections
Multilocus sequence typing
Poland
[SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
MESH: Antigens
Bacterial
Multilocus Sequence Typing
Zdroj: Vaccine
Vaccine, 2016, 34 (4), pp.510-515. ⟨10.1016/j.vaccine.2015.11.070⟩
Vaccine, Elsevier, 2016, 34 (4), pp.510-515. ⟨10.1016/j.vaccine.2015.11.070⟩
ISSN: 1873-2518
0264-410X
Popis: International audience; Neisseria meningitidis of serogroup B (MenB) is currently responsible for more than 70% of cases of invasive meningococcal disease (IMD) in Poland and Europe as a whole. The aim of this study was to estimate strain coverage of a multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland; the meningococcal antigen typing system (MATS) was used to test a panel of 196 invasive MenB strains isolated in Poland in 2010 and 2011. The strains were also characterized by MLST and sequencing of porA, factor H-binding protein (fHbp), Neisserial heparin-binding antigen (nhba) and Neisserial adhesin A (nadA) genes. MATS and molecular data were analyzed independently and in combination. The MATS results predicted that 83.7% (95% CI: 78.6-91.0%) of isolates would be covered by the 4CMenB vaccine; 59.2% by one vaccine antigen, 19.9% by two and 4.6% by three antigens. Coverage by each antigen was as follows: fHbp 73.0% (95% CI: 68.9-77.5%), NHBA 28.6% (95% CI: 13.3-47.4%), NadA 1.0% (95% CI: 1.0-2.0%) and PorA 10.2%. Molecular analysis revealed that the most frequent clonal complexes (ccs) were cc32 (33.2%), cc18 (17.9%) and cc41/44 (15.8%) with estimated coverage of 98.5%, 88.6% and 93.5%, respectively. Consistent with findings for other European countries, our study predicts high coverage by the 4CMenB vaccine in Poland.
Databáze: OpenAIRE
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