Modulatory Action of α-Tocopherol on Erythrocyte Membrane Adenosine Triphosphatase against Radiation Damage in Oral Cancer
| Autor: | Chennam Srinivasulu Shyamaladevi, Subramaniam Chitra |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Physiology medicine.medical_treatment ATPase alpha-Tocopherol Biophysics Internal medicine medicine Humans Tocopherol Na+/K+-ATPase Radiation Injuries Ion channel Aged Adenosine Triphosphatases chemistry.chemical_classification biology Erythrocyte Membrane Cancer Cell Biology Middle Aged medicine.disease Adenosine Radiation therapy Endocrinology Enzyme chemistry Dietary Supplements biology.protein Female Mouth Neoplasms Ca(2+) Mg(2+)-ATPase Sodium-Potassium-Exchanging ATPase medicine.drug |
| Zdroj: | The Journal of Membrane Biology. 240:83-88 |
| ISSN: | 1432-1424 0022-2631 |
| Popis: | To investigate the possible effects of α-tocopherol on erythrocyte membrane adenosine triphosphatases against radiation damage in oral cancer patients. Adenosine triphosphatase activities were analysed in oral cancer patients before and after radiotherapy (at a dosage of 6000 cGY in five fractions per week for a period of six weeks) and after supplemented with α-tocopherol (400 IU per day for entire period of radiotherapy). The membrane bound enzymes such as Na(+)/K(+)-ATPase, Ca(2+)-ATPase, Mg(2+)-ATPase and some trace elements were altered in oral cancer patients before and after radiotherapy. Supplemented with α-tocopherol modulates the erythrocyte membrane which is damaged by radiotherapy which suggests that α-tocopherol protects the erythrocyte membrane from radiation damage in oral cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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